Continuous-flow retro-Diels–Alder reaction: an efficient method for the preparation of pyrimidinone derivatives

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Continuous-flow retro-Diels–Alder reaction: an efficient method for the preparation of pyrimidinone derivatives

The syntheses of various pyrimidinones as potentially bioactive products by means of the highly controlled continuous-flow retro-Diels-Alder reaction of condensed pyrimidinone derivatives are presented. Noteworthy, the use of this approach allowed us to rapidly screen a selection of conditions and quickly confirm the viability of preparing the desired pyrimidinones in short reaction times. Yiel...

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ژورنال

عنوان ژورنال: Beilstein Journal of Organic Chemistry

سال: 2018

ISSN: 1860-5397

DOI: 10.3762/bjoc.14.20